Description
Injectable Excipient Grade – Multi-compendial – High Purity – Low Endotoxin – Low Metals
Molecular Formula : C12H22O11
CAS No : 57-50-1
Molecular Weight: 342.3
Solubility in Water : 200 g/100ml at 25°C
Boiling Point : N/A – decomposes
Melting Point : 185.5 °C
Quality Level : Highest – Parenteral Excipient Grade – GMP / ICH-Q7
Suitable for Injectable Biologic & Vaccine Formulations : DMF # Yes – See Below
Chinese CDE: # Yes – See Below
Pfanstiehl High Purity – Low Endotoxin – Low Metals Sucrose enables Biologic Protein Stabilization and Cryopreservation:
Protein and Antibody Stabilization:
One of the key applications of low endotoxin sucrose (molecular weight 342.3 g/mol) lies in stabilizing proteins and antibodies. Proteins are inherently sensitive to environmental factors such as temperature, pH, and agitation, which can lead to denaturation and loss of biological activity. Sucrose (saccharose) acts as a stabilizing agent by forming hydrogen bonds with proteins, creating a protective environment that shields them from external stressors. This stabilizing effect helps maintain the native conformation of proteins and antibodies, preserving their functionality over time.
Vaccine Stability:
Pfanstiehl Multi-Compendial Sucrose Excipient Grade is widely employed in the stabilization of vaccines, where maintaining the integrity of antigens is crucial for effective immunization. Vaccines often face challenges during storage, transportation, and distribution, including exposure to temperature variations. The addition of pharmaceutical grade sucrose to vaccine formulations creates a glassy matrix that reduces molecular mobility, preventing the denaturation of antigens. This stabilizing effect ensures that vaccines remain potent and efficacious, even under challenging conditions.
Lipid Stabilization:
Lipids, essential components of cell membranes and carriers for drug delivery, are prone to oxidation and degradation. By forming a protective barrier around lipid structures, it prevents the formation of free radicals, preserving the integrity and functionality of lipids. This stabilization is crucial for the development of lipid-based drug delivery systems and other pharmaceutical applications.
Cryopreservation:
Pfanstiehl Low Endotoxin Sucrose is an effective cryopreservative agent, enabling the preservation of biological materials at low temperatures. In cryopreservation, the carbohydrate acts as a cryoprotectant by reducing the formation of ice crystals that can damage cells. Its ability to maintain a glassy state during freezing protects cellular structures and prevents the detrimental effects of ice formation, allowing for the long-term storage of cells, tissues, and biological samples.
Preservation of Stem Cells in Cell Therapy:
In the field of cell therapy, Pfanstiehl pharmaceutical grade sucrose plays a pivotal role in preserving the viability and functionality of stem cells. Stem cells are highly sensitive to changes in their microenvironment, and sucrose helps maintain a stable environment during the freezing and thawing processes. This ensures the successful preservation of stem cells, allowing for their use in various therapeutic applications without compromising their regenerative potential.
